RNA

RNA editing restricts ciliary kinasesCiliary kinases are essential for cilia formation and function but it remains unknown how their activities are regulated in vivo. Li et al. created roundworm animal models carrying hyperactive ciliary…

Machine learning solves RNA puzzlesRNA molecules fold into complex three-dimensional shapes that are difficult to determine experimentally or predict computationally. Understanding these structures may aid in the discovery of drugs for…

RNA solution for a genetic problemPhenylketonuria is a classic example of the benefit of newborn metabolic screening: It is a single-gene disease that can be detected at birth, and its neurological effects can be prevented by dietary…

SummaryOver the past several years, advances in RNA sequencing have led to an increased appreciation of the prevalence and function of noncoding RNAs, including long noncoding RNAs (lncRNAs). These are typically expressed in a…

An antiviral Dicer defends stem cellsStem cells have a pivotal role in maintaining tissue architecture, integrity, and renewal. Poirier et al. demonstrate that mammalian stem cells can protect themselves from some RNA viruses by expressing…

Mind your metalsIron–sulfur clusters are important cofactors for proteins involved in metabolism and electron transfer but are also sometimes found in enzymes involved in transcription and replication of DNA. In vitro expression of such…

Shifting frames to make more proteinsSevere acute respiratory syndrome coronavirus 2 critically depends on the ribosomal frameshifting that occurs between two large open reading frames in its genomic RNA for expression of viral replicase.…

Visualizing Xist RNA dynamicsThe noncoding RNA Xist, which controls the process of X chromosome inactivation in mammals, accumulates and spreads over the chromosome from which it is transcribed. The underlying basis for this unusual…