responses

RESULTSBroad immune remodelling in COVID-19 patientsTo assess the dynamics of immune responses elicited by SARS-CoV-2 infection, we collected PBMCs from COVID-19 patients at the time of acute infection (hereafter indicated as “infection”),…

Vertebrate immune systems must be able to process and respond to myriad intrakingdom and interkingdom interactions by commensals and pathogens. Counterintuitively, Lima-Junior et al. found that colonization of mouse skin by the bacterium…

A virtual memory T cell spectrumVirtual memory T (TVM) cells that acquire a memory phenotype in the absence of foreign antigen are believed to develop in response to self-antigen exposure, but their roles in protective immunity against…

SummaryOther than a placebo-controlled, clinical trial lasting many months and involving tens of thousands of people, is there any way to be sure a COVID-19 vaccine will work? Many researchers say the vaccines already in use offers a…

AbstractOrgan transplant patients have poor immune responses to COVID-19 vaccines; thus designing vaccine strategies to protect this vulnerable population from SARS-CoV-2 infection is crucial.Effective vaccines against viruses, including…

A boost from infectionDuring clinical trials of severe acute respiratory syndrome coronavirus 2 vaccines, no one who had survived infection with the virus was tested. A year after the pandemic was declared, vaccination of previously…

AbstractThe inclusion of infants in the SARS-CoV-2 vaccine roll-out is important to prevent severe complications of pediatric SARS-CoV-2 infections and to limit transmission and could possibly be implemented via the global pediatric vaccine…

Science's COVID-19 reporting is supported by the Heising-Simons FoundationFaced with short supplies of COVID-19 vaccines and unforeseen side effects, some countries have adopted an unproven strategy: switching shots midstream. Most…