Maturation

SummaryHIV-1 particle assembly is driven by the Gag polyprotein precursor, which contains several structural and functional domains that engage in protein-protein, protein-lipid, and protein-RNA interactions during virion assembly.…

Structural changes in HIV maturationNascent HIV particles assemble at the plasma membrane of an infected cell and bud into a membrane-enveloped, immature virion. Assembly and budding are driven by a polyprotein called Gag, which consists of…