immunity

Mom’s IL-6 rewires baby’s gut immunityMost infections that occur during pregnancy are mild and transient. However, whether such pathogen encounters can shape the long-term trajectory of the offspring’s immune system remains unclear. Lim et…

INTRODUCTIONObesity happens when energy intake chronically exceeds energy expenditure. Adipose tissue is essential in regulating whole-body energy homeostasis and is divided into two major types: white adipose tissue (WAT) and brown adipose…

Pax5 regulates mature B cellB cells are a crucial part of adaptive immune responses, so better understanding their development and maturation is crucial. B cell development is controlled by the transcription factor Pax5, but it is not known…

SummaryMammalian stem cells exhibit deficiencies in innate immunity regulated by interferons (IFNs), so they rely on constitutive expression of some IFN-stimulated genes (ISGs) (1) and Argonaute 2 (AGO2)–dependent RNA interference (RNAi)…

Unleashing tumor cDC1Conventional type 1 dendritic cells (cDC1s) perform specialized roles in antitumor immunity by processing and presenting tumor antigens that prime tumor-specific T cell responses. Using a mouse model of immunogenic…

SummaryImmunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a vital issue for global society. Determining the quality and duration of that immunity is therefore key. But the adaptive immune system is…

AbstractPatients with kidney failure are at increased risk for SARS-CoV-2 infection making effective vaccinations a critical need. It is not known how well mRNA vaccines induce B and plasma cell responses in dialysis patients (DP) or kidney…

The right place at the right timeProtective humoral immunity against viral infections requires an effective type 1 immune response by germinal center (GC) T and B cells, a hallmark of which is expression of the transcription factor T-bet.…