gene

Identifying functional genetic variation in humans requires sifting through hundreds of thousands of individual variants and linking them to the trait of interest. We often do not know whether a gene is functional in a tissue or specific…

Vegetal fractalsCauliflower, along with dahlias and daisies, develop as phyllotactic spirals. Azpeitia et al. combined modeling with experimental investigation to clarify the gene-regulatory network that sets up a multitude of undeveloped…

SummaryThe gene editor CRISPR excels at fixing disease mutations in lab-grown cells. But using CRISPR to treat most people with genetic disorders requires clearing an enormous hurdle: getting the molecular scissors into the body and having…

Methyl readers that repress transcriptionDNA methylation is a conserved epigenetic mark required for gene silencing in many different organisms. However, how the methyl mark is able to silence genes is still largely unknown. Ichino et al.…