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DNA repair amplifies transcriptional noiseThe potential role of “noise,” or stochastic variations in rates of gene expression, remains to be elucidated. Desai et al. used screens to identify a compound, 5′-iodo-2′-deoxyuridine (IdU), that…

Exposing unstable TregsThe regulatory T cell (Treg) gene expression program is stably maintained by the transcription factor Foxp3, although certain environmental signals can trigger loss of Foxp3 expression and acquisition of an effector…

Rewiring aged T cellsAge-associated decline in T cell function contributes to impaired immune responses to infection and vaccination. Effector versus memory T cell differentiation is controlled in part by signaling and metabolic…