enzyme

INTRODUCTIONCentral to our understanding of immunity are the signaling pathways of the innate immune system. Prototypical examples include the pathways activated by the Toll-like receptors (TLRs) and the nucleotide-binding leucine-rich…

SummaryPredictive understanding for how a particular amino acid sequence encodes enzymatic function is a grand challenge in molecular biology, with profound impacts in fields ranging from industrial biotechnology, computational protein…

Go big or you'll get lostRational mutagenesis is a common approach to investigating or engineering enzyme function in vitro, but the ease with which one can manipulate protein sequences belies many pitfalls in connecting sparse activity…

How to feed an enzyme ethaneWhen released from ocean floor seeps, small hydrocarbons are rapidly consumed by micro-organisms. Methane is highly abundant and is both produced and consumed by microbes through well understood biochemical…