disease

Childhood malariaUnderstanding how changes in community parasite prevalence alter the rate and age distribution of severe malaria is essential for optimizing control efforts. Paton et al. assessed the incidence of pediatric severe malaria…

Female Anopheles mosquitoes transmit malaria sporozoites to humans in the context of a blood meal. In malaria-endemic areas, most of the ensuing infections are asymptomatic. Some, however, progress to an uncomplicated illness (fever,…

TCR-like antibodies tackle celiac diseaseIngestion of gluten-containing food triggers the gastrointestinal symptoms of celiac disease in patients with CD4+ T cells specific for deamidated gluten peptides presented by disease-associated…

Alzheimer's disease (AD) is characterized by brain protein aggregates of amyloid-β (Aβ) and phosphorylated tau (pTau) that become plaques and tangles, and dystrophic neurites surrounding the plaques, which are accompanied by downstream…

Few of life's experiences evoke greater apprehension than a diagnosis of Alzheimer's disease (AD). Virtually unknown to the public until the 1980s, it is alone among the 10 most common fatal diseases of developed nations in lacking a…

Assays for detecting pathogens are used primarily to diagnose infections. Epidemiologists accumulate results from these tests in time series of case reports to conduct disease surveillance, a cornerstone of public health. During the…

SummaryThe gene editor CRISPR excels at fixing disease mutations in lab-grown cells. But using CRISPR to treat most people with genetic disorders requires clearing an enormous hurdle: getting the molecular scissors into the body and having…

INTRODUCTIONSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing COVID-19, has infected ∼120 million individuals worldwide, displaying a spectrum of disease severities that ranges from asymptomatic to…