COVID19

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or - are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic…

Supplementary materialsimmunology.sciencemag.org/cgi/content/full/6/62/eabl4348/DC1- Figure S1; Ethnicity information and TLR7 allele activity- Figure S2; Allele activity for the TLR8 variants found in our cohort- Figure S3; VirScan…

AbstractThe IMmunoPhenotyping Assessment in a COVID-19 Cohort (IMPACC) is a prospective longitudinal study designed to enroll 1000 hospitalized patients with COVID-19 (NCT04378777). IMPACC collects detailed clinical, laboratory and…

RESULTSBroad immune remodelling in COVID-19 patientsTo assess the dynamics of immune responses elicited by SARS-CoV-2 infection, we collected PBMCs from COVID-19 patients at the time of acute infection (hereafter indicated as “infection”),…

SummarySixteen pandemic months have felt disorienting and arduous—but along the arc of human history, COVID-19 marks just another inflection point. Epidemics have punctuated humanity's timeline for centuries, sowing panic and killing…

Science's COVID-19 reporting is supported by the Heising-Simons FoundationCOVID-19 doesn't strike the genders equally. Globally, for every 10 COVID-19 intensive care unit admissions among women, there are 18 for men; for every 10 women who…

Science's COVID-19 reporting is supported by the Heising-Simons FoundationA nursing home worker in the Netherlands gets a COVID-19 vaccine. A Dutch database lies at the heart of a controversy around a paper on vaccine safety.PHOTO:…

INTRODUCTIONSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing COVID-19, has infected ∼120 million individuals worldwide, displaying a spectrum of disease severities that ranges from asymptomatic to…

AbstractThe side effects of SARS-CoV-2 vaccines are often troubling but may merely reflect transient production of type I interferons, a normal physiological response to contact with invading microorganisms.The development of multiple…

Science's COVID-19 reporting is supported by the Heising-Simons FoundationSome people might want to know their susceptibility to severe COVID-19 before venturing into crowds.PHOTO: APU GOMES/AFP/GETTY IMAGESFor people not yet vaccinated…