At least 25 people are reported to have been killed after what is believed to have been a collision between two trains.
The tragedy is believed to have taken place in Pakistan where dozens of people have also been injured.
Unconfirmed reports on social media and on local news sites claim that the crash took place between the Millat Express and Sir Syed Express in Daharki city, Pakistan.
Video has been shared online appearing to show the aftermath of the disaster, with carriages having come off the rails and now resting on their side.
Rescue teams are said to have been dispatched from Sukkur and Sadiqabad and are expected to reach the area of the crash soon.
Dunya News reports, citing unnamed sources, that the Millat Express was on its way to Sargodha from Karachi while the Sir Syed Express was heading to Karachi from Lahore.
The publication says that the numbers of causalities could rise further as several passengers are still trapped.
Official details of the crash, including the number of dead and injured, have not yet been released by authorities.
Train crashes in the country are relatively common and earlier this year another collision claimed at least one life and injured dozens more.
About 30 people were reportedly left injured when a number of coaches of a Lahore-bound Karachi Express train derailed between Mando Dero and Sanghi railway stations near Rohri in March.
In July last year at least 20 people were reportedly killed when the Shah Hussain Express train slammed into a vehicle near Sheikhupura in Punjab.
Reports said at the time that the dead were largely Sikh pilgrims who were travelling home from Nankana Sahib.
